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bardoxolone methyl
Bardoxolone methyl (also known as “RTA 402”, “CDDO-methyl ester”, and CDDO-Me) is an experimental and orally-available semi-synthetic triterpenoid, based on the scaffold of the natural product oleanolic acid. Pre-clinical studies indicate that the compound acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. A phase 3 clinical trial evaluating bardoxolone methyl for the treatment of chronic kidney disease (CKD) was terminated in October 2012 after patients treated with the drug were found to have experienced a higher rate of heart-related adverse events, including heart failure, hospitalizations, and deaths.〔〔
==Clinical development==
Bardoxolone methyl is being investigated by Reata Pharmaceuticals in a partnership with Abbvie and Kyowa Hakko Kirin.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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